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Dear colleagues, dear GISM members,
It is with deep sorrow that we share with you the news of the passing of an extraordinary person. Last week, we lost Professor Arnold Caplan, a highly esteemed man as a scientist, educator, and visionary.
Professor Caplan, the Director of the Skeletal Research Center at Case Western Reserve University in Cleveland, Ohio (USA), has left an indelible mark in the field of regenerative medicine over an illustrious career spanning more than 50 years.
Born on January 5, 1942, in Chicago, Professor Caplan earned his degree in chemistry from the Illinois Institute of Technology and his doctorate from the Johns Hopkins University School of Medicine. Joining Case Western Reserve University in 1969, he steadily climbed the academic ladder, becoming a professor in 1981 and dedicating an impressive 54 years to the institution.
A pivotal moment in his career was the isolation of human mesenchymal stem cells (MSC) from adult bone marrow, laying the conceptual and technical foundation for subsequent worldwide studies. Recognized as the father of basic science and clinical therapy of adult mesenchymal stem cells, Dr. Caplan discovered the innate ability of MSCs to modulate the immune system, inhibit programmed cell death and scarring, stimulate blood vessel formation, and promote the growth of tissue-specific stem cells. His work influenced the study and treatment of various human diseases, from multiple sclerosis to spinal cord injuries, from cancer to musculoskeletal regenerative medicine. His tireless vision of using cells for the benefit of patients inspired the entire global scientific community.
The warmth and guidance of Professor Caplan touched the lives of countless individuals he mentored, providing growth opportunities to over 150 researchers. His passion extended to sharing his expertise through organizing and participating in high-level courses and conferences, promoting scientific collaboration globally. He received numerous awards, including the Marshall R. Urist Award, the Tissue Engineering and Regenerative Medicine International Society Lifetime Achievement Award, and the Case Western Reserve University Faculty Innovator Award. He authored over 400 articles and held 20 patents. His contributions undeniably shaped the landscape of modern regenerative medicine.
Those who had the honor of knowing him undoubtedly experienced the human side of Arnie, as he liked to be called by friends. Not only a brilliant mentor and scientist but also a man endowed with extreme wit and charm. Professor Caplan consistently showed remarkable openness to the "next gen" of scientists and clinicians. Thanks to his high intelligence and strong empathy, he became an idol for many, extending his influence well beyond the boundaries of his field. Arnie was also a great lover of cuisine, particularly Italian, and in our country, which he adored, he always returned with great pleasure—a pleasure more than reciprocated by those who had the honor of hosting him.
We are deeply grateful to Professor Arnold Caplan for his discoveries, tireless efforts, and the legacy he leaves behind. In his spirit, GISM wishes everyone to continue working to realize those visionary ideals associated with regenerative medicine and contribute to the continuation of his legacy.
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