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GISMOnco

GISM SECTION - "GISM ONCOLOGY"

 

WHO WE ARE

The GISM-Oncology section is dedicated to studying the role of mesenchymal stromal cells (MSCs) in the tumor context, focusing on how these cells influence tumor progression and treatment. Our main areas of interest include:

  • Pro- or anti-tumorigenic role of MSCs: We explore how MSCs can either promote tumor growth or counteract it, depending on the biological and microenvironmental context.
  • Biological and functional characteristics of MSCs in the tumor microenvironment: We delve into the cross-talk between MSCs and tumor cells, with a particular focus on interactions that influence disease progression.
  • In vitro 2D and 3D models of tumors and MSCs: We develop and study advanced in vitro models, such as 3D models, that allow for a more accurate reproduction of tumor-stroma interactions. These models represent a fundamental resource for testing new therapies and better understanding tumor evolution.
  • Using MSCs as vehicles for innovative therapies: We investigate the potential of MSCs as delivery tools for drugs, viruses, cytokines, and exosomes/EVs to develop new therapeutic strategies. This approach can lead to targeted antineoplastic therapies by leveraging the properties of MSCs to precisely deliver therapeutic agents directly to tumor cells.

 

MISSION OF THE GISM-ONCOLOGY

The mission of the GISM-Oncology section is to promote research and innovation in the field of mesenchymal stromal cells (MSCs) applied to oncology, with the aim of thoroughly understanding their role in the tumor microenvironment and developing innovative therapeutic approaches. Through scientific dissemination and continuous education, the section is committed to guiding the scientific community toward new frontiers in oncological research and supporting the adoption of MSC-based therapies in clinical practice.

 

OBJECTIVES OF THE GISM-ONCOLOGY

  • Actively communicate scientific developments in the field of oncology: Promote and disseminate the latest scientific discoveries regarding the role of mesenchymal stromal cells (MSCs) in the tumor microenvironment to encourage informed use of MSCs in oncological research and clinical applications and clarify the scientific foundations of their impact on tumor progression.
  • Building an interdisciplinary community: Encourage the creation of an active network of professionals, including oncologists, biologists, physicians, and researchers, involved in the section's initiatives. GISM-Oncology aims to become a reference point for collaboration and knowledge exchange in the field of MSCs and the tumor microenvironment, fostering continuous dialogue between research and clinical practice.
  • Encourage the development of new therapeutic strategies based on MSCs: Support the development and sharing of innovative protocols for the use of MSCs as therapeutic vectors, including the delivery of drugs, oncolytic viruses, and other bioactive molecules. The goal is to promote a tangible impact on cancer care through targeted and personalized therapies.
  • Disseminate the importance of preclinical models: Raise awareness in the scientific community about the importance of 2D and 3D in vitro models for studying tumor-stroma interactions, promoting their use to improve understanding of tumor biology and accelerate therapeutic innovation.
    These objectives maintain a focus on the importance of scientific communication and the creation of a collaborative network but are specifically oriented toward oncological research and the role of MSCs in tumor dynamics.

 

SCIENTIFIC COMMITTEE

  • Enrico Lucarelli: This email address is being protected from spambots. You need JavaScript enabled to view it. - IRCCS Istituto Ortopedico Rizzoli
  • Katia Mareschi: This email address is being protected from spambots. You need JavaScript enabled to view it. - University of Turin
  • Francesca Paino: This email address is being protected from spambots. You need JavaScript enabled to view it. - University of Milan
  • Andrea Papait: This email address is being protected from spambots. You need JavaScript enabled to view it. - Catholic University of the Sacred Heart, Rome
  • Augusto Pessina: This email address is being protected from spambots. You need JavaScript enabled to view it. - University of Milan

 

PLANNED ACTIVITIES

25/10/2024, Workshop “Cellular models for studying the relationship between stromal cells and tumors.”


Researchers interested in these topics can join GISM by indicating this particular interest to be included in the GISM-Oncology section, to be informed of events, and to suggest initiatives.

>> HOW TO JOIN <<